| 2022-02-15 20:00:00February 15, 2022 | Rayland  | 24 - 10 |  Colerain | N/A | Buckeye East Division Semifinals |
| 2022-02-16 20:00:00February 16, 2022 | Rain City  | 29 - 13 |  Coruscant | N/A | Buckeye West Division Semifinals |
| 2022-02-17 20:00:00February 17, 2022 | Wheeling Island  | 41 - 29 |  Benwood | N/A | Mountaineer West Division Semifinals |
| 2022-02-18 20:00:00February 18, 2022 | Moundsville  | 12 - 17 |  Scranton | N/A | Mountaineer North Division Semifinals |
| 2022-02-19 20:00:00February 19, 2022 | Dublin  | 31 - 24 |  Urbana | N/A | Buckeye North Division Semifinals |
| 2022-02-20 20:00:00February 20, 2022 | Big Pool  | 10 - 13 |  Bridgeville | N/A | Mountaineer North Division Semifinals |
| 2022-02-21 20:00:00February 21, 2022 | Orlando  | 10 - 34 |  Nashville | N/A | Mountaineer South Division Semifinals |
| 2022-02-22 20:00:00February 22, 2022 | Bald Knob  | 10 - 13 |  St. Petersburg | N/A | Mountaineer South Division Semifinals |
| 2022-02-23 20:00:00February 23, 2022 | Tiltonsville  | 42 - 0 |  Yorkville | N/A | Buckeye East Division Semifinals |
| 2022-02-24 20:00:00February 24, 2022 | Athens  | 17 - 20 |  St. Clairsville | N/A | Buckeye South Division Semifinals |
| 2022-02-25 20:00:00February 25, 2022 | Richmond  | 27 - 24 |  Bridgeport | N/A | Mountaineer East Division Semifinals |
| 2022-02-26 20:00:00February 26, 2022 | Mozart  | 24 - 30 |  Wheeling | N/A | Mountaineer West Division Semifinals |
| 2022-02-27 20:00:00February 27, 2022 | San Francisco  | 10 - 7 |  Seattle | N/A | Buckeye West Division Semifinals |
| 2022-02-28 20:00:00February 28, 2022 | Bellefontaine  | 17 - 20 |  Westerville | N/A | Buckeye North Division Semifinals |
| 2022-03-01 20:00:00March 1, 2022 | Vincent  | 24 - 17 |  Duckburg | N/A | Buckeye South Division Semifinals |
| 2022-03-02 20:00:00March 2, 2022 | Annapolis  | 27 - 17 |  Inner City | N/A | Mountaineer East Division Semifinals |
| 2022-03-03 20:00:00March 3, 2022 | Annapolis | 17 - 16 | Richmond | N/A | Mountaineer East Division Finals |
| 2022-03-04 20:00:00March 4, 2022 | Bridgeville | 10 - 14 | Scranton | N/A | Mountaineer North Division Finals |
| 2022-03-05 20:00:00March 5, 2022 | Dublin | 34 - 17 | Westerville | N/A | Buckeye North Division Finals |
| 2022-03-06 20:00:00March 6, 2022 | Wheeling Island | 14 - 35 | Wheeling | N/A | Mountaineer West Division Finals |
| 2022-03-07 20:00:00March 7, 2022 | Vincent | 14 - 21 | St. Clairsville | N/A | Buckeye South Division Finals |
| 2022-03-08 20:00:00March 8, 2022 | Nashville | 13 - 34 | St. Petersburg | N/A | Mountaineer South Division Finals |
| 2022-03-09 20:00:00March 9, 2022 | Tiltonsville | 21 - 20 | Rayland | N/A | Buckeye East Division Finals |
| 2022-03-10 20:00:00March 10, 2022 | San Francisco | 21 - 22 | Rain City | N/A | Buckeye West Division Finals |
| 2022-03-11 20:00:00March 11, 2022 | St. Petersburg | 20 - 17 | Scranton | N/A | Mountaineer Conference Semifinals |
| 2022-03-12 20:00:00March 12, 2022 | Dublin | 18 - 25 | St. Clairsville | N/A | Buckeye Conference Semifinals |
| 2022-03-13 20:00:00March 13, 2022 | Annapolis | 23 - 20 | Wheeling | N/A | Mountaineer Conference Semifinals |
| 2022-03-14 20:00:00March 14, 2022 | Tiltonsville | 27 - 6 | Rain City | N/A | Buckeye Conference Semifinals |
| 2022-03-15 20:00:00March 15, 2022 | Tiltonsville | 20:00:008:00 pm | St. Clairsville | N/A | Buckeye Conference Finals |
| 2022-03-16 20:00:00March 16, 2022 | Annapolis | 20:00:008:00 pm | St. Petersburg | N/A | Mountaineer Conference Finals |
| 2022-03-18 20:00:00March 18, 2022 | | 20:00:008:00 pm | | N/A | League of Nothing Championship |